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Metòd komen pwoteksyon amine

Metòd komen pwoteksyon amine

1. Cbz
Benzyloxycarbonyl (Cbz) Pwoteje Amino
Depwoteksyon N-benzyloxycarbonyl (Cbz)
Souvan itilize réactifs - CbzCl

2. Alloc
Allyloxycarbonyl (Alloc) gwoup amine pwoteje

3. Trifluoroacetyl
Trifluoroacetyl pwoteje gwoup amine

4. Benzyls
p-methoxybenzyl (PMB) pwoteje gwoup amine
2,4-dimethoxybenzyl pwoteje gwoup amine
Benzyl pwoteje amino
Depwoteksyon nan gwoup amino benzyl-pwoteje
N-Bn debenzylation pa metòd chloroformate

5. Pht (phthaloyl)
Phthaloyl (Pht) gwoup amine pwoteje
Depwoteksyon nan gwoup amine phthaloyl-pwoteje

6. Benzenesulfonyl
Nitrobenzenesulfonyl pwoteje gwoup amine
p-toluenesulfonyl (Tos) pwoteksyon amine

7. Trt
Trityl pwoteje amino
Depwoteksyon nan trityl-pwoteje gwoup amine

8. Bok
Tert-butoxicarbonyl pwoteje gwoup amine
Depwoteksyon nan N-tèt-butoxicarbonyl
Oxalyl klori De-Boc

9. Fmoc
Wat methoxycarbonyl pwoteje gwoup amine
Reyaktif souvan itilize - Fmoc-Cl

10. SEM
SEM pwoteje amino

11. Lòt moun
Acetamid pwoteje gwoup amine
Reyaksyon sentèz pirrol Clauson-Kaas (reyaksyon sa a ka itilize kòm yon metòd pou pwoteje gwoup amine, ka ranplase doub pwoteksyon Boc, epi li pi estab)
Souvan itilize reyaktif - benzyl (chloromethyl) etè
Reyaktif souvan itilize - (kloromethyl) etè methyl [MOMCl]
Pwoteksyon Carbamate


Tan pòs: Sep-07-2023